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Design and fabrication of bio-magnetic sensors and magnetic nanobead labels for DNA detection and identification

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9 Author(s)
Wang, S.X. ; Dept. of Mater. Sci. & Eng., Stanford Univ., CA, USA ; White, R.L. ; Li, G.-X. ; Joshi, V.
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In this paper, the main challenges in developing a magnetic DNA microarray include: 1) The spin valve sensors must be sensitive to as few as 1-10 nanobeads to be useful for applications such as biological pathogen detection; to achieve this, the distance between the sensor and magnetic labels must be minimized. 2) The nanobeads must be monodisperse, water soluble, chemically and magnetically stable, and functionalized to attach to a DNA fragment; the nanobeads should also be superparamagnetic so that they will not agglomerate in the absence of applied fields. 3) The bio-magnetic DNA microarrays need to be designed to maximise the active sensing surface area.

Published in:

Magnetics Conference, 2003. INTERMAG 2003. IEEE International

Date of Conference:

March 30 2003-April 3 2003