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Alignment-free sequence comparison with vector quantization and hidden Markov models

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1 Author(s)
Pham, T. ; Sch. of Comput. & Inf. Technol., Griffith Univ., Nathan Campus, Qld., Australia

We introduce the concept of multiresolutions using vector quantization and hidden Markov models as a basis for alignment-free comparison of sequences. Different similarity measures can be discovered at different resolutions of the two sequences. The proposed approach provides a new aspect for studying the complexity of biological data and is effective for real-time processing.

Published in:

Bioinformatics Conference, 2003. CSB 2003. Proceedings of the 2003 IEEE

Date of Conference:

11-14 Aug. 2003