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Bioinformatics is a new and rapidly evolving discipline that has emerged from the fields of experimental molecular biology and biochemistry, and from the artificial intelligence, database, pattern recognition, and algorithms disciplines of computer science. Largely because of the inherently interdisciplinary nature of bioinformatics research, academia has been slow to respond to strong industry and government demands for trained scientists to develop and apply novel bioinformatic techniques to the rapidly growing freely available repositories of genetic and proteomic data. While some institutions are responding to this demand by establishing graduate programs in bioinformatics, the entrance barriers for these programs are high, largely because of the significant amount of prerequisite knowledge in the disparate fields of biochemistry and computer science required for sophisticated new approaches to the analysis and interpretation of bioinformatics data. The authors present an undergraduate-level bioinformatics curriculum in computer science designed for the baccalaureate student. This program is designed to be tailored easily to the needs and resources of a variety of institutions.