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In this paper, we describe the application of a novel spatial fuzzy clustering algorithm to the lip segmentation problem. The proposed spatial fuzzy clustering algorithm is able to take into account both the distributions of data in feature space and the spatial interactions between neighboring pixels during clustering. By appropriate pre- and postprocessing utilizing the color and shape properties of the lip region, successful segmentation of most lip images is possible. Comparative study with some existing lip segmentation algorithms such as the hue filtering algorithm and the fuzzy entropy histogram thresholding algorithm has demonstrated the superior performance of our method.