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Polymer composition, the ratio of lactic acid (LA) to glycolic acid (GA), was evaluated for its contribution to the acoustic enhancement of a poly (co-lactic-glycolic) acid (PLGA) ultrasound contrast agent. Contrast agents were prepared from four different polymer compositions (LA:GA): 100:0, 85:15, 75:25, 50:50 and tested in vivo. The results indicate that all contrast agents perform well in vivo but the 50:50, which had the shortest usable life-time. The performance of the contrast agents was dependent on the ratio of LA to GA and should be considered in the design of polymeric contrast agents.