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Modification of surfactant contrast agent for targeted ultrasound imaging

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5 Author(s)
Oeffinger, B.E. ; Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA ; Lathia, J.D. ; Dhoot, N.O. ; Barbee, K.A.
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Fibronectin peptide fragments were conjugated to a surfactant stabilized ultrasound contrast agent to develop a targeted contrast agent that enhances ultrasound imaging. The agent was modified with PEG and conjugated with a generic GRGDS peptide sequences that targets integrins specific to angiogenesis. The microbubbles bound to human breast cancer cells in vitro within 3 minutes under flow conditions. The GRGDS peptide modified-microbubbles show promise as candidates for targeted therapeutic imaging and eventually drug delivery vehicles.

Published in:

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Date of Conference:

22-23 March 2003