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Fibronectin peptide fragments were conjugated to PIA ultrasound contrast agents to develop a targeted contrast agent that enhances ultrasound imaging. The microspheres were coated with generic GRGDS and REDV peptide sequences that target integrins expressed in angiogenesis, αvβ3 and αvβ5. The microspheres bound to human breast cancer cells in vitro within 3 minutes under flow conditions. The GRGDS and REDV peptide modified microspheres show promise as candidates for targeted therapeutic imaging and eventually drug delivery vehicles.