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The CenSSIS image database is a scientific database that enables effective data management and collaboration to accelerate fundamental research. This paper describes the design and use of a state-of-the-art relational image database management system, accessible through a standard Web-browser interface. The application utilizes a robust security architecture and is designed for efficient data submission. Our database query engine provides complex query capabilities to facilitate fast and efficient data retrieval. The system offers a highly extensible metadata schema, with the option of storing data within a hierarchical format.