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Dynamics of the cell and its extracellular matrix - a simple mathematical approach

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2 Author(s)
Saha, A.K. ; IRIS, Swinburne Univ. of Technol., Melbourne, Vic., Australia ; Mazumdar, J.N.

The extracellular matrix (ECM) is produced by the cells and secreted into the surrounding medium, and consists of a complex mixture of structural and functional proteins. It has been recently observed that the ECM can influence the behavior of cell growth in vitro quite remarkably. A simple mathematical model has been constructed based on negative feedback control mechanisms to represent the dynamics of ECM deposition and cellular differentiation. The model analysis shows a strong relationship between the numerical solution and the experimental observations in cell-polymer constructs for the design of engineered cartilage. The current paper may be a useful guide for those who want to explore the studies on cell-matrix interactions.

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NanoBioscience, IEEE Transactions on  (Volume:2 ,  Issue: 2 )