Cart (Loading....) | Create Account
Close category search window

Incorporation of a fluoroscopic X-ray modality in a small animal imaging system

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

14 Author(s)
Saha, M.S. ; Dept. of Biol., Coll. of William & Mary, Williamsburg, VA, USA ; Bradley, E.L. ; Brewer, P. ; Gleason, K.K.
more authors

The authors have developed a multimodality system for imaging the biodistribution of biologically interesting ligands tagged with 125I. By incorporating a small fluoroscope as an additional modality, they have enhanced their small animal nuclear imaging system to include both X-rays and images from two Hamamatsu R3292 5" diameter position sensitive photomultiplier tubes (PSPMT) viewing pixelated scintillators with image co-registration of 1.5 mm or better. Collimators placed between the animal and the scintillators can easily be interchanged and include CuBe parallel-hole collimators with a range of resolution and sensitivity combinations. The small X-ray fluoroscope provides 5 cm diameter images, several of which can readily be combined to provide structural anatomical information from the animal under study. The system has been tested by comparing the uptake of 125I (in NaI) in control mice and mice previously fed a solution of KI (potassium iodide) designed specifically to block uptake of the radiolabeled iodine in the thyroid. This system not only provides an effective approach for the analysis of KI dose and toxicity issues but also allows for detection of individual variation in animals, an important issue in contemporary pharmacology and genomics.

Published in:

Nuclear Science, IEEE Transactions on  (Volume:50 ,  Issue: 3 )

Date of Publication:

June 2003

Need Help?

IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.