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We consider a circuit paradigm that combines conventional silicon microelectronics with emerging self-assembled nanoelectronics. Peripheral CMOS circuitry is used to drive the input signals and restore the output signals of nanoscale crossbar structures. We address a number of issues dealing with interfacing CMOS and nanoelectronics. Furthermore, we consider important metrics, such as, delay, area, and energy for a full-adder implemented in the mixed circuit paradigm.