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Geometry-based finite-element modeling of the electrical contact between a cultured neuron and a microelectrode

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3 Author(s)
J. R. Buitenweg ; Inst. for Biomed. Technol., Univ. of Twente, Enschede, Netherlands ; W. L. C. Rutten ; E. Marani

The electrical contact between a substrate embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. Interpretation and improvement of these contacts requires proper modeling of all coupling mechanisms. In literature, it is common practice to model the neuron-electrode contact using lumped circuits in which large simplifications are made in the representation of the interface geometry. In this paper, the finite-element method is used to model the neuron-electrode interface, which permits numerical solutions for a variety of interface geometries. The simulation results offer detailed spatial and temporal information about the combined electrical behavior of extracellular volume, electrode-electrolyte interface and neuronal membrane.

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:50 ,  Issue: 4 )