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Two multichannel integrated circuits for neural recording and signal processing

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5 Author(s)
Obeid, I. ; Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA ; Morizio, J.C. ; Moxon, K.A. ; Nicolelis, M.A.L.
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We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage analog signal processor with differential amplification and high-pass filtering. It features selectable gains of 250 and 500 V/V as well as reference channel selection. The resulting amplifiers on Device A had a mean gain of 1.99 V/V with an equivalent input noise of 10 μVrms. Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 μVrms. Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:50 ,  Issue: 2 )