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In this paper, the problem of blind space-time constrained multiuser detection for asynchronous DS-CDMA systems operating in multipath channels is considered. Multiple linear prediction is applied to estimate the column vector subspace of the channel matrix using only the spreading code of the desired user, which is used to construct the interference suppression constraint. At each antenna, intersymbol interference (ISI) and multiple access interference (MAI) are simultaneously suppressed by novel space-time constrained multiuser detection. Outputs from each antenna are combined to get the final receiver decision statistic. Optimal combining weight is derived. Simulations demonstrate the effectiveness of the proposed scheme.