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Modeling electric field transfer of excitation at cell junctions

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2 Author(s)
Sperelakis, Nicholas ; Dept. of Molecular & Cellular Physiol., Univ. of Cincinnati Coll. of Medicine, OH, USA ; Ramasamy, L.

The electric field (EF) model was first developed on a "breadboard" using physical electric components (e.g., resistors, capacitors, batteries) and was then modeled mathematically by a series of differential equations and matrix equations and simulated on a large computer (CDC-6400). The results obtained by the two methods agreed very closely. However, these two methods of analysis are quite cumbersome. Therefore, in order to simplify the EF simulation, we wanted to model it on the PSpice program. In this article we discuss how we succeeded in demonstrating transmission of excitation from cell to cell in cardiac muscle and smooth muscle based on EF transmission at the cell junctions.

Published in:

Engineering in Medicine and Biology Magazine, IEEE  (Volume:21 ,  Issue: 6 )

Date of Publication:

Nov.-Dec. 2002

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