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Business process re-engineering has overcome the hype of the nineties of the last century and has become an engineering discipline. With the advent of e-business a new era of uncertainty in systems' development has arrived. Do current approaches extend to e-business engineering, or are there too many essential differences to prevent this? In this paper we discuss the similarities and difference between business process engineering and e-business engineering, based on research and cases that we have carried out over the last seven years. From this analysis we digest what support is needed for engineers in e-business and relate this to current approaches in e-business.