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Use of simulation for capacity analysis is an upcoming field in Biotech industry. This paper discusses an application of discrete event simulation in the multi-product and multi-resource Filling Freeze Drying facility of Bayer Corporation's Berkeley site. The SIGMA® simulation model was used to estimate the current and future throughput capacity by taking into account current operations and various capital and efficiency improvement projects planned for near future. The model also identified certain project clusters with potential for large capacity gains, which otherwise would not have been visible. The model and its outcome are in use since 2001.