By Topic

Computation of the fluid-induced shear stress in bioreactor-cultured 3D cell systems

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

9 Author(s)
Boschetti, F. ; Lab. of Biol. Struct. Mech., Politecnico di Milano, Milan, Italy ; Raimondi, M.T. ; Fiore, G.B. ; Dubini, G.
more authors

Fluid-induced shear is known to enhance chondrogenesis on animal cells. We have developed a computational fluid dynamic model of the flow through chondrocyte seeded scaffolds cultured inside a novel bioreactor in which the culture medium flows through the constructs' microstructure. The median shear stress imposed to the cells in the bioreactor culture, as predicted by the CFD model, is 3·10-3 Pa at a flow rate of 0.5 ml/min corresponding to an inlet fluid velocity of 4.42·10-5 m/s. Providing a fluid-dynamic environment to the cells yielded significant differences in cell morphology.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:1 )

Date of Conference: