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Computation of the fluid-induced shear stress in bioreactor-cultured 3D cell systems

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9 Author(s)
Boschetti, F. ; Lab. of Biol. Struct. Mech., Politecnico di Milano, Milan, Italy ; Raimondi, M.T. ; Fiore, G.B. ; Dubini, G.
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Fluid-induced shear is known to enhance chondrogenesis on animal cells. We have developed a computational fluid dynamic model of the flow through chondrocyte seeded scaffolds cultured inside a novel bioreactor in which the culture medium flows through the constructs' microstructure. The median shear stress imposed to the cells in the bioreactor culture, as predicted by the CFD model, is 3·10-3 Pa at a flow rate of 0.5 ml/min corresponding to an inlet fluid velocity of 4.42·10-5 m/s. Providing a fluid-dynamic environment to the cells yielded significant differences in cell morphology.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:1 )

Date of Conference:

2002