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Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

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4 Author(s)
M. L. Upton ; Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA ; J. Chen ; F. Guilak ; L. A. Setton

The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

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Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:1 )

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