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Two techniques for localized 2450-MHz hyperthermia of experimental mouse cancers are described. In the far-field approach superficial tumors are encapsulated in 5-cm mold-formed spheres of semi-solid phantom material, then placed in an anechoic chamber on an equipower surface. In the applicator approach, tissues are immersed in a temperature-controlled tissue-equivalent liquid bolus, and are irradiated by time-multiplexed parallel-opposed beams. Both techniques feature microwave bolusing for improved coupling and tumor heating uniformity.