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The effects of microwave radiation, hyperthermia, and L-ascorbic acid on metabolism of (U-14C) glucose, (2-14C) glucose, and (1,5-14C) citrate in Ehrlich ascites tumor cells (EATC) were studied. Microwave irradiated and water bath incubated cells were maintained at the same temperature for comparison. Data were obtained at 37.5°C and 42.5°C in the presence or absence of L-ascorbic acid. Ascorbic acid increased the rate of metabolism of both glucose and citrate. No significant differences in glucose and citrate metabolism were found between irradiated and nonirradiated cells at the same temperature and ascorbic acid concentration. A comparison of glucose metabolism in a normal tissue preparation and EATC was made. Vitamin C did not increase metabolism in the normal cell preparation.