By Topic

Comparative in vivo and ex vivo pacing and sensing performance study using isolated four-chamber working swine heart model

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Laske, T.G. ; Dept. of Anesthesiology, Minnesota Univ., Minneapolis, MN, USA ; Skadsberg, N.D. ; Iaizzo, P.A.

A study was conducted comparing the pacing and sensing performance of an endocardial pacing lead (5076, Medtronic, Inc., Minneapolis, MN) in vivo to an ex vivo isolated heart model designed to work all four chambers under simulated in vivo physiologic conditions. The lead was implanted in vivo using fluoroscopic guidance. Standard stimulation and sensing parameters were recorded. Using standard cardiac surgical techniques, 8 porcine hearts were excised and reperfused in a working heart model retaining their original lead placement. Following stabilization, the electrical measurements were repeated. Ex vivo electrical values were significantly decreased relative to the in vivo measurements: R-wave amplitude by 39%, P-wave amplitude by 39%, slew rate by 62%, and pacing impedance by 34%. Pacing threshold values were similar in vivo and ex vivo. Variations in performance were in part attributed to local tissue deformation in the isolated heart preparation leading to differences in lead slack and orientation. This comparative study substantiated the value of utilizing the isolated heart model to visualize and simultaneously evaluate lead pacing and sensing performance in comparison with in vivo experimental procedures.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:2 )

Date of Conference: