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A general SPICE-transmission-line matrix (TLM) interconnection framework has been developed. The connection algorithm is based on the representation of the TLM network by equivalent Thevenin and/or Norton sources. Fundamental issues such as source equivalence and SPICE-TLM interconnection options have been examined. The framework opens new and far-reaching possibilities for hybrid global microwave and high-speed digital circuit modeling in the time domain because it combines the extensive circuit and device models of SPICE with general three-dimensional field solutions.