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Digital communication systems are frequently operated over nonlinear channels with memory. The analysis of the performance of these systems is difficult and no complete analytical treatment of the problem has been obtained before. Several recent efforts have been directed toward the computation of error probabilities via Monte-Carlo simulation using a complete system model. These simulations require excessively large sample sizes and are not practical for estimating very low values of error probabilities. This paper presents a modified Monte-Carlo simulation technique for estimating error probabilities in digital communication systems operating over nonlinear channels. An importance-sampling technique is used to modify the probability density function of the noise process in a way to make simulation possible. Theoretical results as well as realistic examples are presented, showing that the number of samples needed for simulation is reduced considerably.