Immunosensor for C-reactive protein using anti-CRP monoclonal antibody and its F(AB')/sub 2/ fragment immobilized quartz crystal microbalance

We present the detection method of C-reactive protein (CRP) using anti-CRP antibody and its F(ab')/sub 2/ fragment immobilized quartz crystal microbalance (QCM). The present QCM method is detectable in the range 1 ng/dL to 100 /spl mu/g/dL of CRP concentration.