Amplification of 10.6-μm radiation in a metallic waveguide and waveguide CO2-laser action was achieved by excitation of the CO2(0001) mode by vibrational energy transfer from metastable molecules. Excitation of N2was accomplished in a separate dc discharge tube. The N2-He mixture, after flowing through the discharge region, was pumped into the waveguide and there CO2was added. Maximum small-signal gain values of 25.6 and 15.3 dB/m were obtained at amplifying waveguide sections of 2 and 6-cm length, respectively. A theoretical analysis, based on rate equations for the (0001) and the (1000) states of CO2and the concentration of molecules, is presented, which leads to predictions for the small-signal gain and the saturation intensity. In the pressure range covered by experiments the calculated gain values were found to be consistent with measurements.