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Molecular specific contrast agents to enhance optical imaging of precancers

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7 Author(s)
Sokolov, K. ; Dept. of Biomed. Eng., Texas Univ., Austin, TX, USA ; Aaron, J. ; Pavlova, I. ; Lotaw, R.
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In this paper, we bring together the advances of in vivo optical imaging and modern nano-chemistry to permit optical imaging with molecular specificity. We present optically interrogated contrast agents based on metal nanocrystals attached to probe molecules with a high affinity to a specific biomarker on the surface of epithelial cancer cells. We demonstrated that unique optical properties of metal nanoparticles can be used to develop novel optically-interrogatable contrast agents for confocal reflectance imaging of pre-cancers.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002