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Optical sectioning wide-field microscopy for imaging oral cancer

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7 Author(s)
Abd-El-Barr, M.M. ; Dept. of Biomed. Eng., Univ. of Texas, Austin, TX, USA ; Hsu, E.R. ; Anslyn, E.V. ; Descour, M.R.
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We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002