Cart (Loading....) | Create Account
Close category search window
 

Spaceflight conditions alter human immunity and predispose to infection and cancer

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

6 Author(s)
Shearer, W.T. ; Nat. Space Biomed. Res. Inst., Baylor Coll. of Med., Houston, TX, USA ; Butel, J.S. ; Reuben, J.M. ; Gridey, D.S.
more authors

It is likely that the human immune system will be damaged in astronauts exposed to the conditions of long-term spaceflight: isolation, containment, microgravity, radiation, and microbial contamination. In all human and animal subjects flown in space, there is evidence of immune compromise, reactivation of latent virus infection, and development of a pre-malignant or malignant condition. Moreover, in all ground-based spaceflight model investigations there is again evidence of immune compromise and reactivation of latent virus infection. Studies are in progress to determine whether malignancy, too, will be observed in experimental animals. All of these observations in spaceflight itself, or in ground-based models of spaceflight, find strong resonance in a wealth of human pathological conditions involving the immune system where reactivated virus infections and cancer appear as a natural consequence. Human immune systems compromised by stress, immunosuppressive drugs, infection, and radiation are known to lead to states of chronic infection and cancer development. The clinical conditions of EBV-driven lymphomas in transplanted patients and Kaposi sarcoma in AIDS patients come easily to mind in trying to identify these conditions. With these thoughts in mind, therefore, it is highly appropriate that careful investigations of human immunity, infection, and cancer be made by spaceflight researchers.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.