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Collectively our findings clearly suggest that in the model of spinal isolation (SI) which causes rapid levels of atrophy and protein loss, there occurs 1) a marked reduction in the capacity to maintain mRNA substrate for key proteins (MHC and actin) which comprise the backbone of the muscle; 2) this occurs by decreases in transcriptional activity of the key marker genes; 3) a reduction in total RNA of which the majority is ribosomal or the prime machinery to perform protein synthesis; and 4) likely an increase in expression of enzymes involved in protein degradation. Thus these patterns are consistent with the rapid net loss is protein that occurs during the first 8 days following SI treatment and continues to about 16 days at which time the muscle reaches a new steady state of reduced/maintained muscle mass.
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint (Volume:3 )
Date of Conference: 23-26 Oct. 2002