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Effect of a hyperpolarization-activated inward current on rhythmic activity in a hybrid half-center oscillator

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4 Author(s)
Sorensen, M. ; Lab. for Neuroengineering, Emory Univ., Atlanta, GA, USA ; Cymbalyuk, G. ; Calabrese, R. ; DeWeerth, S.

A hybrid half-center oscillator, composed of a living neuron and an analog very large scale integrated circuit (aVLSI) model neuron connected via dynamic clamp has been constructed. This hybrid oscillator is designed to mimic the behavior of a living half-center found in Hirudo medicinalis, the medicinal leech. Using our hybrid system, we have investigated the effect of modulating a hyperpolarization-activated inward current on the oscillatory properties of the half-center.

Published in:

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint  (Volume:3 )

Date of Conference:

23-26 Oct. 2002