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CANCER is a reasonably general circuit analysis program especially suited to integrated-circuit simulation. The program provides for the analysis of large circuits in the following four modes of operation: nonlinear d.c., large-signal transient, small-signal a.c., and thermal and shot noise. These subanalysis capabilities are intercoupled appropriately for convenience and efficiency. Internally, CANCER is a very general nodal analysis program that derives its efficiency from the exploitation of sparse matrix, adjoint, and implicit integration techniques.