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This article explains a modeling methodology of human physiology. An agent-based approach to a physiological digital human is proposed, and its design concept and architectural framework are discussed. The modeling is based on two types of agents: stationary agents which model human physiology, and mobile agents that model parameter interaction between the user and the human physiological model. The human thermoregulatory system is chosen as an example of model functions. A Java-based agent system is shown as an implementation of the model.