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Kinetic studies of molecular recognition on DNA by using a 27 MHz QCM

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1 Author(s)
Okahata, Y. ; Dept. of Biomolecular Eng., Tokyo Inst. of Technol., Yokohama, Japan

We introduce a 27-MHz quartz-crystal microbalance (QCM) as a new tool to detect DNA-protein/peptide interactions in an aqueous solution. We undertook observations of a various protein/peptide (for example, histone and transcription factors such as a zinc-finger type peptide or a leucine-zipper type peptide) binding onto double strand DNA (dsDNA) included their binding site.

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Sensors, 2002. Proceedings of IEEE  (Volume:1 )

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