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Summary from only given. We demonstrate the operation of a link with high immunity to supply and substrate noise. A total link power penalty of only 0.12 dB/ 100 mV of receiver supply noise was observed. Link performance was unaffected by substrate noise injection from a voltage controlled oscillator (VCO). This high immunity can be attributed to the differential nature of the receiver. The effect of supply noise and crosstalk on electrically single-ended receivers has been studied. To the best of our knowledge, however, this is the first demonstration of the operation of an entire chip-to-chip optical link with modulators and electrically differential receivers quantifying the effect of supply and substrate noise.