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Bit-wise three-dimensional data storage techniques are attractive candidates to increase capacity. Two major bit-wise volumetric data storage techniques have been proposed. The first one is based on a two-photon fluorescent material. The second one is based on materials that change their refractive index. Simulations based on 3D optical transfer functions are described that predict the signal, cross talk and signal to noise ratio of different bit-wise volumetric read out systems. Experimental results based on a fluorescent material are presented.