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Information in any field, including bioinformatics, is a combination of data and the data's context. A system that manages information must be able to handle both aspects of information: context and data. The problem with most systems (databases in particular) is that the context must be predefined. In a field that is developing as fast as bioinformatics, it is as impossible to predefine all of the context as it is to predefine all of the data that is being generated. A knowledge management system must handle context or metadata as freely and flexibly as it handles data. NeoCore has developed a fully extensible, schema independent, XML-based information management system that meets this requirement.