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The competitive adsorption between collagen and bovine serum albumin (BSA) was investigated by imaging ellipsometry. The competitive adsorption of the binary solution depended on the surface chemistry of substrates. At the range of concentration investigated, collagen preferentially adsorbed on the hydroxy surface (-OH surface) but BSA on the methylic surface (-CH3 surface). ROS 17/2.8 cell adhesion on the two kinds of surfaces with or without the pre-adsorption of protein was also investigated. The results showed that the competitive adsorption caused ROS 17/2.8 cells to preferentially adhere and spread well on the -OH surface, but they had less adherence and didn't spread on the -CH3 surface.