By Topic

A model-based crosstalk compensation method for simultaneous Tl-201 and Tc-99m dual isotope myocardial SPECT imaging

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Wang, W.T. ; Dept. of Biomed. Eng., North Carolina Univ., Chapel Hill, NC, USA ; Frey, E.C. ; Tsui, B.M.W. ; Tocharoenchai, C.

Clinical use of Tl-201 and Tc-99m dual isotope myocardial SPECT requires compensation for crosstalk contamination of the Tl-210 data. The most significant sources of the crosstalk are Tc-99m downscatter and Pb X-rays generated by the interaction of Tc-99m photons with the collimator. In this work we evaluated a model-based crosstalk compensation method using experimental data acquired from a torso phantom with a cardiac insert. This model-based method incorporated downscatter and Pb X-ray models to estimate and thus compensate the contamination. A cold lesion was placed in an inferior apical myocardial region of the cardiac insert. Long acquisitions were performed to obtain high-count projection data in Tl and Tc energy windows. Separately acquired Tl-201 and Tc-99m projection images were appropriately scaled and summed together to simulate separate and simultaneous acquisitions. Noisy projection images were generated by simulating Poisson noise using the high-count projection images. A total of 100 noise realizations of the projection images were used to study the image noise levels. The reconstructed Tl-201 images of simultaneous acquisition were compared to those of separate acquisition in terms of image noise and defect contrast. It was found that the model-based crosstalk compensation method substantially improved the lesion visualization and lesion contrast in the Tl images and reduced quantitative errors in polar maps. A contrast-noise curve showed that the model-based method resulted in an improved contrast-noise trade-off compared to images without crosstalk compensation. In conclusion, the results of this preliminary evaluation indicate that the model-based method is promising. However, more detailed development and evaluation of the model-based method is required to its clinical utility

Published in:

Nuclear Science Symposium Conference Record, 2001 IEEE  (Volume:4 )

Date of Conference:

2001