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Global optimization of protein 3-dimensional structures in NMR by a genetic algorithm

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6 Author(s)
I. Ono ; Fac. of Eng., Tokushima Univ., Japan ; H. Fujiki ; M. Ootsuka ; N. Nakashima
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Protein three-dimensional structure determination is one of the most important problems in molecular biology. Nuclear magnetic resonance (NMR) spectroscopy is one of the promising techniques capable of determining the three-dimensional structures of proteins at atomic resolution. In determining protein structures using NMR spectroscopy, nuclear Overhauser effect (NOE) signal assignment is the most laborious and time-consuming process. Attempts to automate NOE signal assignment have failed so far. In this paper, we propose a new automatic assignment method of NOE signals based on a real-coded genetic algorithm and examine its effectiveness by applying it to determining the structure of an α-helix, which is a well-known common substructure of proteins, and a protein called HMG2B

Published in:

Evolutionary Computation, 2002. CEC '02. Proceedings of the 2002 Congress on  (Volume:1 )

Date of Conference:

12-17 May 2002