By Topic

Modulation of drug delivery rate by hydrogel-incorporating MEMS devices

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Yuandong Gu ; Dept. of Pharm., Minnesota Univ., Minneapolis, MN, USA ; Baldi, A. ; Ziaie, B. ; Siegel, R.A.

We describe two approaches for modulating fluid flow and drug delivery rate in response to external stimuli using hydrogels incorporated in MEMS devices. The first design, a hydrogel-gated flow controller (HFC), consists of two components, a 3-dimensional crosscut structure and a loaded hydrogel. For a temperature-sensitive HFC, temperature cycling between 25 and 40°C results in a flow rate change between 0 and 12 ml/minute, with a 30 second response time. In the second design, a hydrogel-actuated microvalve (HAM) was constructed. In such a device, a hydrogel disc is sandwiched between a porous plate and a flexible silicone rubber membrane. Swelling of the hydrogel produced by diffusion of chemical species through the porous plate, resulting in the deflection of the membrane and closure of the valve intake orifice. A HAM loaded with phenylboronic acid (PBA)-based glucose-sensitive hydrogel was tested. This glucose-sensitive HAM opens and closes in response to changes in glucose concentration and pH. The fastest response time achieved was 16 minutes using a 70 μm thick hydrogel and a 60 μm porous back plate

Published in:

Microtechnologies in Medicine & Biology 2nd Annual International IEEE-EMB Special Topic Conference on

Date of Conference:

2002