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In this paper, other spot-beam interference value is studied based on a mobile satellite system (MSS) compatible with TD-SCDMA by theoretical analysis and numerical simulation. A system model to calculate the interference value is presented by making assumptions such as perfect power control and uniformly distributed users. Numerical results of other spot-beam interference value with different frequency reuse factors and different spot-beam overlap values are obtained. Additionally, the influence of other spot-beam interference value is shown by an example of network design, which shows the mobile satellite system compatible with TD-SCDMA should use frequency reuse factor 1.