By Topic

A screening method for dimensionality reduction in biochemical reaction system calibration

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Jenkinson, W.G. ; Whitaker Biomed. Eng. Inst., Johns Hopkins Univ., Baltimore, MD, USA ; Goutsias, J.

Estimating the rate constants of a biochemical reaction model of cellular function is an important, albeit computationally intensive, problem in systems biology. In this paper, a variance-based sensitivity analysis approach is proposed, which can be used, as a pre-screening step, to identify parameters in a biochemical reaction system that do not appreciably influence the cost of estimation and, therefore, whose values cannot be precisely determined by parameter estimation. By only estimating the remaining parameters, appreciable qualitative and quantitative improvements can be achieved. A subset of a well-known biochemical reaction model of the EGF/ERK signaling pathway is used to illustrate the benefits achieved by the proposed method.

Published in:

Genomic Signal Processing and Statistics (GENSIPS), 2010 IEEE International Workshop on

Date of Conference:

10-12 Nov. 2010