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Communication networks have evolved tremendously over the past several decades, offering a multitude of services while becoming an essential critical infrastructure in our daily lives. Networks in general, and the Internet in particular face a number of challenges to normal operation, including attacks and large-scale disasters, as well as due to the characteristics of the mobile wireless communication environment. It is therefore vital to have a framework and methodology for understanding the impact of challenges to harden current networks and improve the design of future networks. In this paper, we present a framework to evaluate network dependability and performability in the face of challenges. This framework uses ns-3 simulation as the methodology for analysis of the effects of perturbations to normal operation of the networks, with a challenge specification applied to the network topology. This framework can simulate both static and dynamic challenges based on the failure or wireless-impairment of individual components, as well as modelling geographically-correlated failures. We demonstrate this framework with the Sprint Rocketfuel and synthetically generated topologies as well as a wireless example, to show that this framework can provide valuable insight for the analysis and design of resilient networks.