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This paper reports an effective optimization procedure for designing no-moving part microvalves where the diodicity of the optimized valves has better performance when compared with the typical Tesla valve. The detailed layout of microvalves is obtained by minimizing the fluidic resistance of fluidic channels for the forward flow under a user-specified design constraint about the fluidic work diodicity between the forward and reverse flows. A couple of novel valves which have different layout with the Tesla valve are presented. The numerical value of the fluidic resistance diodicity for a designed periodic valve is verified by experiments.