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Adaptation of a minimal four-state cell model for reproducing atrial excitation properties

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7 Author(s)
Weber, F.M. ; Univ. Karlsruhe (TH), Karlsruhe ; Lurz, S. ; Keller, D.U.J. ; Weiss, D.L.
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Simulation of cardiac excitation is often a trade-off between accuracy and speed. A promising minimal, time-efficient cell model with four state variables has recently been presented together with parametrizations for ventricular cell behaviour. In this work, we adapt the model parameters to reproduce atrial excitation properties as given by the Courtemanche model. The action potential shape is considered as well as the restitution of action potential duration and conduction velocity. Simulation times in a single cell and a tissue patch are compared between the two models. We further present the simulation of a sinus beat on the atria in a realistic 3D geometry using the fitted minimal model in a monodomain simulation.

Published in:

Computers in Cardiology, 2008

Date of Conference:

14-17 Sept. 2008