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Label-Free Fiber Optic Biosensors With Enhanced Sensitivity

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5 Author(s)

A sensitivity-enhanced long-period grating in-fiber Michelson interferometer with diameter-reduced cladding was proposed for the first time, and was also demonstrated as a label-free biosensor based on refractive index measurement. The cladding structure dependence of the sensitivity for antibody-antigen immuno-sensing was studied experimentally. The proposed biosensor has shown an 8.5-fold sensitivity enhancement as compared to sensors without cladding reduction.

Published in:

IEEE Journal of Selected Topics in Quantum Electronics  (Volume:13 ,  Issue: 6 )