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The objective of this paper is to analyze the impact of liquid surface tension on force measurement in submerged micromanipulation. First, at present, mechanical characterization of biological objects in biological liquid is of significant interest. Second, the reduction of the surface force and adhesion forces in a submerged medium could be a relevant approach to perform reliable artificial objects micromanipulation. In both cases, the micro-nano force measurement in a liquid is a great challenge. In the case of a force sensor placed out of the liquid, the measurement is disturbed by the liquid surface tension. This paper proposes an analysis of these disturbances on force measurements. Some design rules are proposed to reduce disturbances. We show that the major disturbances are induced by the contact angle hysteresis, and a complete method is proposed to calculate these disturbances in a micromanipulation task.