By Topic

Assignment of terminal penalties in controlling genetic regulatory networks

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
A. Choudhary ; Dept. of Electr. Eng., Texas A&M Univ., College Station, TX, USA ; A. Datta ; M. L. Bittner ; E. R. Dougherty

Probabilistic Boolean networks have been used to model inter-gene relationships and their dynamic behavior. Optimal control of such networks has been proposed by turning on or off individual genes. Though this problem was solved in an earlier work by using a dynamic programming algorithm, issues regarding the assignment of terminal penalties and selection of genes for intervention were not addressed. In this work, we provide an algorithm for assigning terminal penalties, taking long term uncontrolled behavior into account. We also discuss the possibility of using gene influence for pre selection of genes to be used for intervention. This is implemented for the popular WNT5A network.

Published in:

Proceedings of the 2005, American Control Conference, 2005.

Date of Conference:

8-10 June 2005