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This paper presents a low noise electrochemical interface circuit that is tuned to the needs of protein-based biosensor arrays and compatible with the formation of fully integrated biochemical microsystems. The circuit includes an integrated potentiostat and highly sensitive amperometric readout amplifier. It achieves good noise performance while supporting biosensor output currents from 10 pA to 10 μA to suit a wide range of sensitivities and electrode areas. Implemented in 0.5 μm CMOS process, it is compatible with a post-CMOS process to realize an integrated biosensor array.